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胃肠道间质瘤病理诊断研究进展

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胃肠道间质瘤属于消化道系统肿瘤的主要类型,虽然,该疾病并非几大常见肿瘤,但却存在比较明显的基因突变以及转移现象,会给患者带来更为严重的损伤.从临床角度上来看,该病可能存在于消化系统的多个区域,最高发的区域是胃部,其次是小肠部位,随后依次是结肠、直肠以及食管,也有可能在肠系膜等部位出现.该病并没有特定的患病年龄群,任何年龄段的人群都有可能患胃肠道间质瘤,但绝大多数的患者集中在50~80岁,而且男性患者数量要略多于女性患者.研究表明绝大多数小尺寸胃肠道间质瘤在发病初期并未展现出明显的临床特征,但随着肿瘤不断增长,患者会逐渐表现出腹部不适、腹部肿大、食欲不振、吞咽障碍、消化道出血等症状.如果得不到及时有效的治疗,患者极有可能会因为肿瘤不断增长而出现肿瘤破裂或者胃肠道梗阻,严重危及患者的身体健康和生命安全.本文综述了胃肠道间质瘤病理诊断研究进展,以期为胃肠道间质瘤的临床诊断提供指导.
Research progress in pathological diagnosis of gastrointestinal stromal tumor
Gastrointestinal stromal tumor belongs to the main type of digestive system tumors.Although this disease is not one of the most common tumors,there are significant genetic mutations and metastasis phenomena,which can cause more serious damage to patients.From a clinical perspective,this disease may exist in multiple regions of the digestive system,with the highest incidence occurring in the stomach,followed by the small intestine,followed by the colon,rectum and esophagus,and may also occur in the mesentery and other areas.There is no specific age group for this disease,and any age group may develop gastrointestinal stromal tumors.However,the vast majority of patients are concentrated between the ages of 50-80,and the number of male patients is slightly higher than that of female patients.Research has shown that the vast majority of small-sized gastrointestinal stromal tumors do not exhibit obvious clinical features in the early stages of onset.However,as the tumor continues to grow,patients will gradually exhibit symptoms such as abdominal discomfort,abdominal enlargement,loss of appetite,swallowing disorders and gastrointestinal bleeding.If not treated promptly and effectively,patients are highly likely to experience tumor rupture or gastrointestinal obstruction due to the continuous growth of the tumor,which seriously endangers the personal health and life safety of patients.This article reviews the research progress in pathological diagnosis of gastrointestinal stromal tumors,in order to provide guidance for the clinical diagnosis of gastrointestinal stromal tumors.

Gastrointestinal stromal tumorPathological diagnosisHistology

李丹

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天津市宝坻区人民医院病理科,天津医科大学宝坻临床学院,天津 301800

胃肠道间质瘤 病理诊断 组织学

2024

中国城乡企业卫生
中华预防医学会 天津市职业病防治院

中国城乡企业卫生

影响因子:0.239
ISSN:1003-5052
年,卷(期):2024.39(5)