Research progress on potential value of lncRNA in diagnosis,treatment and prognosis of oral cancer
Oral squamous cell carcinoma(OSCC)is one of the most common malignancies worldwide.The overall prognosis is poor,and the 5-year overall survival rate is about 50％.Early diagnosis and early treatment are the basic methods to improve the cure rate and prognosis of patients.The early diagnosis and treatment of OSCC has been a problem for a long time.With the continuous progress of treatment technology,we have changed from simple early detection and treatment of diseases to looking for the root cause of diseases,that is,looking for the causes of diseases at the gene level and treating diseases.A total of 60％-70％of the human genome transcriptome is composed of non-coding RNA.Although non-coding RNA lack the potential to encode proteins and peptides,they can participate in normal human physiological activities by regulating gene expression.Long non-coding RNA(lncRNA)are considered to be key elements of gene regulation,and play a key role in the occurrence and development of various human cancers.More and more studies have confirmed that lncRNA is associated with the occurrence and prognosis of OSCC.This article reviews the research progress on the expression and clinical impact of OSCC related lncRNA,aiming to focus on the possible molecular mechanism of lncRNA's involvement in OSCC carcinogenesis and progression,and explore the potential clinical application of lncRNA as a biomarker for early diagnosis,prognosis assessment and treatment target of OSCC.
万方数据
维普
