Research progress on the correlation between vitamin D deficiency and hypertension
Hypertension is a common cardiovascular disease,the disability and mortality rates are both relatively high.Vitamin D is an essential nutrient for the human body,which can increase the body's absorption of Ca2+,thus further promote the Ca2+deposition.Vitamin D deficiency can lead to a series of the diseases.The 7-dehydrogenation cholesteryl in the body is converted into vitamin D3,which is transported to the liver,under the action of hydroxylase convertes into 25-hydroxyl vitamin D[25(OH)D],combines with the protein,then it reaches the kidney,after in the role of 1 alpha hydroxylase,generates calcitriol(1,25-dihydroxy vitamin D),it can be combined with vitamin D receptor(a class of ligands relying on nuclear transcription factor),thus plays a biological effect,and then affects gene transcription.The possible mechanism by which vitamin D deficiency causes hypertension disease includes:activate the renin-angiotensin-aldosterone system(RAAS)and parathyroid function,affect the body's vascular endothelial cell function,increase the insulin resistance,increase of nitric oxide synthase,affect function of vascular smooth muscle cells,vascular sclerosis of arterial congee appearance and calcification,genetic genes.For hypertensive population,vitamin D supplementation can improve the incidence of adverse cardiovascular events of patients.However,the study on cardiovascular mortality of vitamin D supplementation lacks in-depth analysis with large sample size,so more clinical trial data are needed for in-depth study.This article reviews the research progress on the correlation between vitamin D deficiency and hypertension,in order to provide assistance for the treatment of hypertension.
Vitamin D deficiencyHypertensionCorrelationCalcium ionAdverse cardiovascular eventsAdditional doses
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