Effect of acarbose combined with metformin in the treatment of type 2 diabetes mellitus
Objective To explore the clinical efficacy of acarbose combined with metformin in the treatment of type 2 diabetes mellitus,and to find a better treatment method to control blood sugar of patients.Methods A total of 200 patients with type 2 diabetes mellitus admitted to Hubei Province Wuhan City Wuchang District Shuiguohu Street Community Health Service Center from February 2019 to November 2021 were selected to be included in the study.They were divided into control group and observation group by double-blind method,with 100 cases in each group.The control group was treated with metformin,and the observation group was treated with acarbose combined with metformin.The fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin and the incidence of adverse reactions of the two groups were compared.Results Before intervention,there were no significant differences in blood glucose indicators between two groups(P＞0.05).After intervention,in the observation group,the fasting blood glucose was(5.21±1.09)mmol/L,2 h postprandial blood glucose was(7.07±1.55)mmol/L,and glycosylated hemoglobin was(6.31±0.22)％,which were lower than(6.54±1.67)mmol/L,(8.89±1.87)mmol/L and(7.09±0.51)％respectively in the control group,and the differences were statistically significant(P＜0.05).The incidence of adverse reactions in the observation group was 6.00％,and the incidence of adverse reactions in the control group was 4.00％,there was no significant difference between the two groups(P＞0.05).Conclusion For the treatment of type 2 diabetes mellitus,acarbose combined with metformin could significantly improve blood glucose level and reduce the incidence of adverse reactions,which was worthy of clinical promotion and application.
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