Research progress of warfarin interactions with commonly used drugs for cardiovascular disease
Warfarin have the most obvious drug interaction among non-genetic factors of drugs,so it is necessary to understand the characteristics and effects of warfarin in clinical application.The warfarin drug interactions include pharmacodynamics and pharmacokinetics.Pharmacodynamic aspets:through the influence of vitamin K synthesis,metabolism and utilization,the anticoagulation effect is produced.Pharmacokinetic aspets:(1)through binding to digestive tract mucosa,it affects the absorption of warfarin;(2)warfarin metabolism can be reduced and the concentration of warfarin in patients can be increased by interfering CYPs;(3)warfarin distribution is affected,the binding effect of warfarin with non-protein is increased,and its anticoagulant effect is enhanced.Interaction drugs include commonly used cardiotonic drugs(digoxin),anti-arrhythmia drugs(amiodarone),lipid-lowering drugs(pravastatin,fluvastatin,etc.),antiplatelet drugs(clopidogrel,aspirin,etc.),uric acid lowering drugs(benbromarone),proton pump inhibitors and hypoglycemic drugs(metformin).Warfarin's anticoagulant effect can be affected by its interactions with other drugs.Therefore,the research progress of warfarin interaction with commonly used drugs for cardiovascular diseases was reviewed,in order to provide guidance for the clinical application of warfarin.
WarfarinCardiovascular diseaseCommonly used drugsDrug interactionLipid-lowering drugsAntiarrhythmic drugs
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