Observation on the relationship between blood glucose fluctuations and bone mineral density in postmenopausal T2DM patients
Objective To explore the relationship between blood glucose fluctuation and bone mineral density in postmenopausal type 2 diabetes mellitus(T2DM)patients,so as to provide reference for clinical treatment of postmenopausal T2DM patients.Methods From August 2021 to August 2023,110 postmenopausal patients with T2DM treated in Jiangsu Province Nanjing City Liuhe District People's Hospital were selected.According to T value,they were divided into normal bone mass group with 37 cases,bone mass loss group with 41 cases and osteoporosis group with 32 cases.All enrolled patients wore a scanning glucose monitoring instrument(FGM)to record the changes of mean blood glucose(MBG),time within target range(TIR),standard deviation of blood glucose(SD),coefficient of variation of blood glucose(CV),mean fluctuation amplitude of blood glucose(MAGE)and other indicators.The relationships between bone mineral density and biochemical indicators,blood glucose fluctuation indicators in postmenopausal T2DM patients were analyzed.Results With bone mineral density decreased,age and course of diabetes mellitus increased,BMI decreased.The age,course of diabetes mellitus and BMI of osteoporosis group were compared with those of normal bone mass group,and the differences were statistically significant(P＜0.05).Blood glucose fluctuations:as bone mineral density decreased,HbAlc,SD,CV and MAGE levels all increased,and TIR showed a decreasing trend;there were statistically significant differences in the comparsion of three group of CV,MAGE and TIR(P＜0.05);there was no statistically significant difference in MBG levels among the three groups(P＞0.05).The analysis of lumbar spine bone mineral density in patients showed a negative correlation with age and course of disease(r=-0.315,-0.301,P＜0.05).In blood glucose fluctuations,HbAlc,SD,CV and MAGE were all negatively correlated with bone mineral density(r=-0.249,-0.315,-0.313,-0.275,P＜0.05),while TIR was positively correlated with bone mineral density(r=0.387,P＜0.05).Conclusion There was a certain correlation between bone mineral density and blood glucose fluctuation indicators in postmenopausal T2DM patients.TIR was a key factor leading to decreased bone mass.Controlling blood glucose fluctuations could delay the decline in bone mineral density,at same time,monitoring blood glucose fluctuations was beneficial for preventing osteoporosis in postmenopausal T2DM patients.
Ttype 2 diabetes mellitusBlood glucose fluctuationsBone mineral density
万方数据
维普
