Two directions that cannot be ignored in the study of endemic fluorosis and endemic arsenicosis in China: long-term exposure to low-dose fluoride and arsenic, and non-target organ damage
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随着我国地方性氟中毒（地氟病）、地方性砷中毒（地砷病）防治措施全面落实，按照世界卫生组织（WHO）饮用水推荐标准和我国日人均氟允许摄入量与饮用水砷含量限值标准，我国居民进入了低氟、低砷剂量暴露的时代。但是，迄今国内外对低氟、低砷剂量暴露的远期健康效应的研究不多，更忽视了对非靶器官的研究，结论也不尽一致，亟须开展系统的研究，予以阐明。据此，本文提出了建立低氟、低砷暴露人群队列，系统开展低氟、低砷暴露健康远期效应及其机制研究和向"一带一路"国家推广中国防治经验的建议，旨在为我国新形势下地氟病、地砷病防治策略与措施的制定提供科学依据。 With the comprehensive implementation of prevention and control measures for endemic fluorosis and endemic arsenicosis in China, and in accordance with the World Health Organization (WHO) recommended drinking water standards and the Chinese standards of allowable daily fluoride intake and limit values of arsenic content in drinking water, Chinese residents have entered the era of low-dose fluoride and arsenic exposure. However, there have been few studies focused on the long-term health effects of exposure to low-dose fluoride and arsenic both domestically and internationally. Further more, study on non-target organs of fluoride and arsenic has been neglected. The conclusions are also inconsistent, and there is an urgent need for systematic study to clarify them. Accordingly, this paper proposes to establish a cohort of people exposed to low-dose fluoride and arsenic, systematically carry out study on the long-term health effects and mechanisms of low-dose fluoride and arsenic exposure, and promote China's prevention and control experience to the "the Belt and Road" countries, in order to provide a scientific basis for the formulation of prevention and control strategies and measures for endemic fluorosis and endemic arsenicosis under the new situation in China.
With the comprehensive implementation of prevention and control measures for endemic fluorosis and endemic arsenicosis in China, and in accordance with the World Health Organization (WHO) recommended drinking water standards and the Chinese standards of allowable daily fluoride intake and limit values of arsenic content in drinking water, Chinese residents have entered the era of low-dose fluoride and arsenic exposure. However, there have been few studies focused on the long-term health effects of exposure to low-dose fluoride and arsenic both domestically and internationally. Further more, study on non-target organs of fluoride and arsenic has been neglected. The conclusions are also inconsistent, and there is an urgent need for systematic study to clarify them. Accordingly, this paper proposes to establish a cohort of people exposed to low-dose fluoride and arsenic, systematically carry out study on the long-term health effects and mechanisms of low-dose fluoride and arsenic exposure, and promote China's prevention and control experience to the "the Belt and Road" countries, in order to provide a scientific basis for the formulation of prevention and control strategies and measures for endemic fluorosis and endemic arsenicosis under the new situation in China.
Low-dose fluoride exposureLow-dose arsenic exposureLong-term health effectsNon-target organsDamage
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