Clinical characteristics of brucellosis patients combined with osteoarthritis
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目的 分析布鲁氏菌病合并骨关节炎患者临床症状及实验室特征。 方法 回顾性分析2021年1月至2022年12月在山东省济宁市公共卫生医疗中心住院治疗的168例布鲁氏菌病患者的病历资料，并根据影像学检查结果分为合并骨关节炎组和非合并骨关节炎组，比较分析两组患者人口学特征、临床症状和实验室检查结果。 结果 168例布鲁氏菌病患者中，合并骨关节炎患者组83例、非合并骨关节炎患者组85例，男、女性别比为2.73 ∶ 1.00（123 ∶ 45），年龄为56（46，64）岁；合并骨关节炎组患者年龄中位数高于非合并骨关节炎组（58岁比53岁，Z = - 2.89，P = 0.004）。临床症状中，合并骨关节炎组患者腰背痛、乏力、关节肌肉疼痛发生率均高于非合并骨关节炎组[75.9%（63/83）比56.5%（48/85），30.1%（25/83）比15.3%（13/85），47.0%（39/83）比17.6%（15/85），χ2 = 7.07、5.27、16.58，均P < 0.05]；实验室检查中，合并骨关节炎组红细胞沉降率（ESR）和超敏C-反应蛋白（hs-CRP）均高于非合并骨关节炎组[27.0（17.0，34.0）mm/h比21.0（10.5，34.0）mm/h，22.7（14.3，43.4）mg/L比17.9（10.8，34.2）mg/L， Z = - 2.51、- 2.00，均P < 0.05]。合并骨关节炎组患者中，以合并脊柱炎占比最高（55.4%，46/83），其次是外周关节炎（51.8%，43/83）。 结论 骨关节炎是布鲁氏菌病常见的并发症，布鲁氏菌病合并骨关节炎患者更易出现腰背痛、乏力、关节肌肉疼痛等临床症状，且ESR和hs-CRP水平均较高。 Objective To analyze the clinical symptoms and laboratory characteristics of patients with brucellosis combined with osteoarthritis. Methods A retrospective analysis was conducted on the medical records of 168 patients with brucellosis who were hospitalized at the Jining Public Health Medical Center, Shandong Province from January 2021 to December 2022. Based on the imaging examination results, they were divided into combined osteoarthritis group and non combined osteoarthritis group. The demographic characteristics, clinical symptoms, and laboratory test results of the two groups of patients were compared and analyzed. Results Among 168 patients with brucellosis, there were 83 patients with concurrent osteoarthritis, 85 patients without concurrent osteoarthritis, the males and females ratio was 2.73 ∶ 1.00 (123 ∶ 45), and the age was 56 (46, 64) years old. The median age of patients in combined osteoarthritis group was higher than that of patients in non combined osteoarthritis group (58 years vs 53 years, Z = - 2.89, P = 0.004). In clinical symptoms, the incidence of back pain, fatigue, and joint muscle pain in patients of combined osteoarthritis group was significantly higher than that in the non combined osteoarthritis group [75.9% (63/83) vs 56.5% (48/85), 30.1% (25/83) vs 15.3% (13/85), 47.0% (39/83) vs 17.6% (15/85), χ 2 = 7.07, 5.27, 16.58, P < 0.05]. In laboratory tests, the erythrocyte sedimentation rate (ESR) and hypersensitive C-reactive protein (hs-CRP) levels in patients of combined osteoarthritis group were higher than those in the non combined osteoarthritis group [27.0 (17.0, 34.0) mm/h vs 21.0 (10.5, 34.0) mm/h, 22.7 (14.3, 43.4) mg/L vs 17.9 (10.8, 34.2) mg/L, Z = - 2.51, - 2.00, P < 0.05]. Among patients with combined osteoarthritis, combined spondylitis accounted for the highest proportion (55.4%, 46/83), followed by peripheral arthritis (51.8%, 43/83). Conclusion Osteoarthritis is a common complication of brucellosis, and patients of brucellosis with concurrent osteoarthritis have clinical features such as lower back pain, fatigue, and joint muscle pain, with significantly elevated of ESR and hs-CRP level.
Objective To analyze the clinical symptoms and laboratory characteristics of patients with brucellosis combined with osteoarthritis. Methods A retrospective analysis was conducted on the medical records of 168 patients with brucellosis who were hospitalized at the Jining Public Health Medical Center, Shandong Province from January 2021 to December 2022. Based on the imaging examination results, they were divided into combined osteoarthritis group and non combined osteoarthritis group. The demographic characteristics, clinical symptoms, and laboratory test results of the two groups of patients were compared and analyzed. Results Among 168 patients with brucellosis, there were 83 patients with concurrent osteoarthritis, 85 patients without concurrent osteoarthritis, the males and females ratio was 2.73 ∶ 1.00 (123 ∶ 45), and the age was 56 (46, 64) years old. The median age of patients in combined osteoarthritis group was higher than that of patients in non combined osteoarthritis group (58 years vs 53 years, Z = - 2.89, P = 0.004). In clinical symptoms, the incidence of back pain, fatigue, and joint muscle pain in patients of combined osteoarthritis group was significantly higher than that in the non combined osteoarthritis group [75.9% (63/83) vs 56.5% (48/85), 30.1% (25/83) vs 15.3% (13/85), 47.0% (39/83) vs 17.6% (15/85), χ 2 = 7.07, 5.27, 16.58, P < 0.05]. In laboratory tests, the erythrocyte sedimentation rate (ESR) and hypersensitive C-reactive protein (hs-CRP) levels in patients of combined osteoarthritis group were higher than those in the non combined osteoarthritis group [27.0 (17.0, 34.0) mm/h vs 21.0 (10.5, 34.0) mm/h, 22.7 (14.3, 43.4) mg/L vs 17.9 (10.8, 34.2) mg/L, Z = - 2.51, - 2.00, P < 0.05]. Among patients with combined osteoarthritis, combined spondylitis accounted for the highest proportion (55.4%, 46/83), followed by peripheral arthritis (51.8%, 43/83). Conclusion Osteoarthritis is a common complication of brucellosis, and patients of brucellosis with concurrent osteoarthritis have clinical features such as lower back pain, fatigue, and joint muscle pain, with significantly elevated of ESR and hs-CRP level.
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