Research progress on the effect of fluoride on bone marrow mesenchymal stem cells
吴雨航 1李喜功 2潘文明 3张钦 1吴师菲
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作者信息
1. 山西医科大学附属运城市中心医院骨科，运城 044000
2. 浙江大学医学院附属第一医院骨科，杭州 310003
3. 常熟市第二人民医院骨科，常熟 215500
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摘要
氟是自然界广泛存在的一种重要元素，适量摄入可预防龋齿、促进骨骼发育。但长期过量摄入，可引发氟中毒，损害牙齿、骨骼、心肌、血管等组织或器官。骨髓间充质干细胞（BMSCs）凭借自身多向的分化潜能特性在骨损伤的修复过程中发挥着重要作用。因此，研究BMSCs对治疗因氟中毒所致的氟骨症具有重要意义。本文总结了氟化物对BMSCs影响及作用机制的研究进展，为氟骨症发病机制研究和临床治疗提供新的思路。 Fluorine is an important element widely present in nature, and moderate intake can prevent dental caries and promote bone development. However, long-term excessive intake can lead to fluorosis, damaging tissues or organs such as teeth, bones, heart muscle, and blood vessels. Bone marrow mesenchymal stem cells (BMSCs) play an important role in the repair process of bone injury due to their excellent multi-directional differentiation potential. Therefore, studying BMSCs is of great value in the treatment of fluorosis caused by fluoride poisoning. This article summarize the progress on the effect of fluoride on BMSCs, providing new ideas for the study of the pathogenesis and clinical treatment of fluorosis.
Abstract
Fluorine is an important element widely present in nature, and moderate intake can prevent dental caries and promote bone development. However, long-term excessive intake can lead to fluorosis, damaging tissues or organs such as teeth, bones, heart muscle, and blood vessels. Bone marrow mesenchymal stem cells (BMSCs) play an important role in the repair process of bone injury due to their excellent multi-directional differentiation potential. Therefore, studying BMSCs is of great value in the treatment of fluorosis caused by fluoride poisoning. This article summarize the progress on the effect of fluoride on BMSCs, providing new ideas for the study of the pathogenesis and clinical treatment of fluorosis.
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