Research progress of hypoxia inducible factors in cardiovascular diseases
Hypoxia inducible factors(HIF)are hypoxia-sensitive transcription factors that are the primary regulators of the cellular response to hypoxia.Hypoxia inducible factors induce inflammation,lipid metabolism,endothe-lial dysfunction,proliferation of vascular smooth muscle cells(VSMC),and regulate the development of cardiovascular dis-eases(CVD).This paper reviews the role of hypoxia inducible factors in CVD and the progress of the mechanism of ac-tion in recent years,and discusses the role and mechanism of hypoxia inducible factors on vascular constituent cell types and its relationship with the occurrence and development of CVD.It can provide a reference for analyzing the pathogenesis of CVD and discovering new therapeutic targets.The aim is to provide a theoretical reference for further understanding the role and mechanism of hypoxia inducible factors in the pathogenesis of CVD,and to provide a basis for the design of novel effective therapeutic agents targeting hypoxia inducible factors.
万方数据
维普
