Mechanisms of NLRP3 inflammasome in atherosclerosis and advances in targeted in-flammatory therapy
Atherosclerosis(As)is a pathological process caused by a complex set of factors,including endothelial dysfunction,lipid deposition in the arterial vessel wall,macrophage infiltration,smooth muscle cell dysfunction,and foam cell formation,in which inflammatory response plays an indispensable role.NOD-like receptor protein 3(NLRP3)in-flammasomes are transducers of inflammatory cells,and NLRP3 inflammasome activation mediates the inflammatory response and activates downstream interleukin-18 and interleukin-1 β,thereby participating in the occurrence and develop-ment of As.Therefore,specific inhibitors targeting NLRP3 inflammasome and downstream inflammatory factors are poten-tial targets for current clinical drug research and are expected to be a new therapeutic measure for treating As.In this arti-cle,the mechanism of NLRP3 inflammasome and the relationship with As are discussed,and drugs targeting NLRP3 in-flammasome and downstream inflammatory factors are also described.
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