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非酒精性脂肪性肝病国内外诊疗指南的区别及治疗展望

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非酒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗和遗传易感性密切相关的、肝脏脂肪过度堆积的代谢应激性肝脏损伤.据估计,目前世界上25%的人口被诊断患有NAFLD,对社会经济发展和人们的健康水平造成巨大影响.基于不同地区的生活习俗和人群基因差异,NAFLD在各国/地区的流行率不同,并且在NAFLD诊断标准和治疗方案上各国/地区诊疗指南给出的推荐也存在一定差异.该综述旨在对比国内外最新指南在NAFLD诊断与治疗方面的异同点,汇总最新诊疗手段研究进展,以期对NAFLD的临床诊疗提供借鉴.
Differences in the diagnosis and treatment guidelines at home and abroad for non-al-coholic fatty liver disease and treatment prospects
Non-alcoholic fatty liver disease(NAFLD),a metabolic stress-induced liver injury,is characterized by excessive accumulation of fat in the liver,which is closely related to insulin resistance and genetic susceptibility.It is es-timated that 25%of the world's population are currently diagnosed with NAFLD,which has a huge impact on socioeconomic development and people's health.The prevalence of NAFLD in different countries/regions is different based on the living customs and population genetic differences in different regions,and there are also certain differences in the diagnostic crite-ria and treatment plans of NAFLD in the recommendations given by the national/regional diagnosis and treatment guide-lines.This article aims to compare the latest domestic and international guidelines on the diagnosis and treatment of NAFLD,as well as summarise the latest research advances in the treatment of NAFLD,in order to provide recommenda-tions for the clinical management of NAFLD.

non-alcoholic fatty liver diseasemetabolic associated fatty liver diseasediagnosis and treatment guidelinesmedical treatment

黎翔、陈弋、刘霞、孙旸

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海军军医大学药学院,上海市 200433

非酒精性脂肪性肝病 代谢相关脂肪肝病 诊疗指南 药物治疗

国家自然科学基金项目上海市"科技创新行动计划"项目上海市"科技创新行动计划"项目

8207390720ZR147010020S11902700

2024

中国动脉硬化杂志
中国病理生理学会 南华大学

中国动脉硬化杂志

CSTPCD
影响因子:1.086
ISSN:1007-3949
年,卷(期):2024.32(4)