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血管壁面剪切应力对动脉粥样硬化和动脉瘤的影响

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血管壁面剪切应力是血流动力学的重要参数,正常的壁面剪切应力维持了血管的生理状态,而异常的壁面剪切应力与动脉粥样硬化和动脉瘤的病理进展关系密切,是发生恶性心脑血管事件的危险因素之一.异常的壁面剪切应力通过不同发病机制破坏了内皮细胞的正常功能,介导这两种疾病的起始、演变.文章结合近几年来的文献研究,综述了壁面剪切应力对动脉粥样硬化和动脉瘤的影响.
The effect of wall shear stress on atherosclerosis and aneurysm
Wall shear stress is an important parameter in hemodynamics.Normal wall shear stress maintains the physiological state of blood vessels,while abnormal wall shear stress is closely related to the pathological progression of ath-erosclerosis and aneurysm,which is one of the risk factors for the occurrence of malignant cardiovascular and cerebrovascu-lar events.Abnormal wall shear stress destroys the normal function of endothelial cells through different pathogenesis,mediates the initiation and evolution of these two diseases.This article reviews the impact of wall shear stress on athero-sclerosis and aneurysm based on literature research in recent years.

wall shear stressatherosclerosisaneurysmhemodynamics

李淑妍、陶新宇、曲晨

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南京医科大学第二附属医院老年医学科,江苏省南京市 210011

壁面剪切应力 动脉粥样硬化 动脉瘤 血流动力学

国家自然科学基金面上项目

81971317

2024

中国动脉硬化杂志
中国病理生理学会 南华大学

中国动脉硬化杂志

CSTPCD
影响因子:1.086
ISSN:1007-3949
年,卷(期):2024.32(5)