首页|人类疾病中线粒体异常形态的研究进展

人类疾病中线粒体异常形态的研究进展

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线粒体是真核生物细胞内的"发电机",对于细胞各种生命活动的正常进行至关重要.除了为细胞供能外,线粒体还参与一些重要的细胞活动,如凋亡、分化和增殖等.但线粒体并不是"永动机".事实上,线粒体是对多种病理条件最为敏感的细胞器之一.线粒体功能障碍可导致多种人类疾病,如阿尔茨海默病、糖尿病、缺血性心脏病等.众所周知,线粒体形态的改变会影响其功能,反之亦然.在病理条件下线粒体会发生多种形态改变.以异常线粒体形态为特征的研究使研究者能够了解线粒体在某些人类疾病发病机制中的作用.本综述主要总结了人类疾病中线粒体形态变化的研究进展,旨在提供一定的理论概述.
Research progress on abnormal mitochondrial morphology in human diseases
Mitochondria are the"power generators"in eukaryotic cells,therefore playing vital roles for basically all cellular activities.Not only supplying energy,mitochondria are also actively regulating important cellular processes,such as apoptosis,differentiation,and proliferation.But mitochondria are not"perpetual motion machines".In fact,mito-chondria are one of the most sensitive organelles to various pathological conditions.Dysfunction of mitochondria can cause many human diseases,such as Alzheimer's disease,diabetes,ischemic heart disease,etc.It is well known that changes in mitochondrial morphology affect the mitochondrial function,and vice versa.Under pathological conditions,mitochondria undergo various morphological changes.Research studies that characterized abnormal mitochondrial mor-phology have enabled us to understand the mitochondrial involvement in the pathogenesis of certain human diseases.This review mainly summarizes the research progress on mitochondrial morphological changes in human diseases,aiming to pro-vide a theoretical overview.

human diseasesmitochondriaabnormal morphology

李依、王丹玲

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南华大学衡阳医学院,湖南省衡阳市 421001

人类疾病 线粒体 异常形态

湖南省科技创新重点工程课题湖南省普通高等学校教学改革研究项目

2021SK1014HNJG-2020-0440

2024

中国动脉硬化杂志
中国病理生理学会 南华大学

中国动脉硬化杂志

CSTPCD
影响因子:1.086
ISSN:1007-3949
年,卷(期):2024.32(6)