The role and mechanism of N6-methyladenosine modification in atherosclerosis
Atherosclerosis(As)is the pathological basis of various vascular diseases,which affects the function of important organs.Recent studies have found that N6-methyladenosine(m6A)modification plays a vital role in As.This paper summarizes the regulatory effects of m6A modification on vascular endothelial cell(VEC)injury,vascular smooth muscle cell(VSMC)transformation,macrophage(Mø)differentiation,foam cell(FC)formation,pyroptosis,and lipid regulation,and summarizes the regulation function of some m6 A regulatory proteins in As.
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