Atherosclerotic calcified nodule is rare but important cause of coronary artery thrombosis and acute coro-nary syndrome.Eruptive calcified nodule is characterized by clusters of burst like calcified fragments protruding into the lumen accompanied by ruptured fibrous caps and thrombus attached to the surface,which is a potential cause of sudden car-diac death.The prognosis of acute coronary syndrome caused by calcified nodule is poor,and the incidence of periopera-tive myocardial infarction,cardiac death,and target lesion revascularization is high.This article reviews the progress in the diagnosis and treatment of atherosclerotic calcified nodule in coronary artery.