Research progress of TLR4 in acute myocardial infarction and its treatment
Acute myocardial infarction(AMI)is a severe disease caused by the persistent coronary artery obstruc-tion,posing a great threat to people's health.In recent years,Toll-like receptor4(TLR4),an important pattern recogni-tion receptor,has been widely studied and found to play a crucial role in AMI.This review introduces the recent progress of TLR4 in regulating the progression and prognosis of AMI,and summarizes recent TLR4-targeted therapies using clinical drugs,TLR4 inhibitors,mesenchymal stem cells,and natural bioactive molecules,providing valuable insights for address-ing myocardial damage caused by AMI and improving prognosis.
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