首页|基于肾藏精理论探讨中医药调控维生素D在泛血管疾病中的作用

基于肾藏精理论探讨中医药调控维生素D在泛血管疾病中的作用

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动脉粥样硬化(As)是由于脂质沉积而引起的慢性炎症性病变,以As为最主要引发因素的泛血管疾病逐渐受到诸多学者的关注,其主要病理特征为血管病变.维生素D作为肾藏精的物质基础,在泛血管疾病中发挥重要的抗As作用,参与泛血管疾病的肾素-血管紧张素系统(RAS)调控、内皮细胞损伤、免疫反应改变、中性粒细胞胞外诱捕网调节、细胞凋亡和自噬等多个病理过程,是诸多研究中的新靶点.而中医药在泛血管疾病的防治中具有一定优势,其中药单味药、活性成分及复方可调控维生素D相关代谢,并对泛血管疾病的防治具有独特科学价值.该文主要对维生素D在动脉粥样硬化性泛血管疾病多个病理环节中的作用及相关中医药干预进行探讨,旨在从维生素D角度为中医药防治泛血管疾病提供有效思路.
The role of Traditional Chinese Medicine in regulating vitamin D in panvascular dis-eases based on kidney storing essence
Atherosclerosis(As)is a chronic inflammatory disease caused by lipid deposition.Panvascular disea-ses,which are mainly caused by As,have gradually attracted the attention of many scholars,and their main pathological features are vascular lesions.Vitamin D plays an important role in anti-As in panvascular diseases.It is involved in the regulation of renin-angiotensin system(RAS),endothelial cell injury,immune response,neutrophil extracellular traps(NET)regulation,apoptosis and autophagy,and is a new target in panvascular diseases research.Traditional Chinese Medicine(TCM)has certain advantages in the prevention and treatment of panvascular diseases.Among them,single herbs,active ingredients and compound prescriptions can regulate vitamin D-related metabolism,and have unique scientific value for the prevention and treatment of As.This article mainly discusses the role of vitamin D in multiple pathological links of panvascular diseases and related Chinese medicine interventions,aiming to provide effective ideas for the prevention and treatment of panvascular diseases from the perspective of vitamin D.

panvascular diseasesatherosclerosisvitamin DTraditional Chinese Medicinekidney storing essence

李倩、柴艺汇、李文、高洁、秦忠、王焕珍、管连城、陈云志

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贵州中医药大学,贵州省贵阳市 550025

德江县民族中医院,贵州省铜仁市 565200

贵州中医药大学第二附属医院,贵州省贵阳市 550002

泛血管疾病 动脉粥样硬化 维生素D 中医药 肾藏精理论

国家自然科学基金项目贵州省教育厅滚动支持省属高校科研平台团队项目2022年贵州中医药大学研究生教育创新计划项目

82260890黔教技[2022]023号YCXZRB202209

2024

中国动脉硬化杂志
中国病理生理学会 南华大学

中国动脉硬化杂志

CSTPCD
影响因子:1.086
ISSN:1007-3949
年,卷(期):2024.32(8)
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