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双向两样本孟德尔随机化分析失眠与心肌梗死的因果关系

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[目的]采用双向两样本孟德尔随机化(MR)分析失眠与心肌梗死(MI)之间的关联.[方法]从全基因组关联研究(GWAS)中获取MI的遗传关联数据,选择失眠表型相关的单核苷酸多态性(SNP)作为工具变量.以逆方差加权法(IVW)为主要方法评估失眠与MI之间的因果关系.[结果]MR分析表明,失眠与MI发病存在正向关联[IVW:优势比(OR)=1.015,95%可信区间(CI)1.004~1.027,P=0.007],工具变量不存在水平多效性与异质性,敏感性分析提示MR分析结果稳定.反向MR分析提示MI与失眠风险增加之间无因果关系(IVW:OR=0.725,95%CI 0.466~1.126,P=0.152),去除离群值之后统计结果稳定.[结论]失眠是MI的危险因素,失眠与MI发病存在正向关联.但MI与失眠风险增加不存在因果关系.
Bidirectional two-sample Mendelian randomization study of insomnia and myocardial infarction
Aim To explore the association between insomnia and myocardial infarction(MI)using bidirectional two-sample Mendelian randomization(MR).Methods The summary statistics of MI were obtained from genome-wide association studies(GWAS),and single nucleotide polymorphisms(SNP)associated with insomnia phenotype were select-ed as instrumental variables.Inverse variance weighting(IVW)was used to evaluate the causal relationship between in-somnia and MI.Results MR analysis showed that there was positive relationship between insomnia and MI(IVW:OR=1.015,95%CI 1.004~1.027,P=0.007).There was no horizontal pleiotropy and heterogeneity in instrumental variables.Sensitivity analysis suggested that MR analysis results were stable.Reverse MR analysis showed no causal re-lationship between MI and increased risk of insomnia(IVW:OR=0.725,95%CI 0.466~1.126,P=0.152),and the statistical results were stable after the removal of outliers.Conclusion Insomnia is a risk factor for MI and there was positive relationship between insomnia and MI.However,there was no causal relationship between MI and an increased risk of insomnia.

insomniamyocardial infarctionMendelian randomizationrisk factor

于龙、李英伟

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天津市津南医院心血管内科,天津市 300350

失眠 心肌梗死 孟德尔随机化 危险因素

2024

中国动脉硬化杂志
中国病理生理学会 南华大学

中国动脉硬化杂志

CSTPCD
影响因子:1.086
ISSN:1007-3949
年,卷(期):2024.32(9)
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