Research advance in the influencing factors of pubertal timing
Adolescence is a critical period for sexual maturation and physical growth,and the time of the first appearance of events during puberty initiation is called puberty timing.Recent studies have shown that abnormal changes in the pubertal timing are mainly influenced by genetic,environmental,nutritional,ethnic,and early-life factors.This review focuses on the current research progress of factors influencing puberty onset phase and related disease,in order to provide theoretical basis for prevention of clinical related diseases.
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