Relative importance of nutritional and metabolic related indicators in blood for obesity in children aged 1-6 years based on random forest algorithm
Objective To explore the relative importance of nutritional and metabolic indicators in blood based on random forest algorithm in overweight and obesity among children aged 1-6 years,in order to provide reference for clinical evaluation of childhood obesity and development of nutritional plans.Methods Children aged 1-6 years who were admitted to the Children's Healthcare Department of the Daxing District Maternal and Child Health Hospital of Beijing from February 2021 to May 2022 were selected as study subjects,and were divided into normal group(n=400),overweight group(n=200),and obesity group(n=200).Blood related indicators among the three groups were compared,and multivariate Logistic regression analysis was used to explore the related factors of childhood obesity.The variable relative importance of random forest was obtained through SPSS Modeler,and the variables were sorted.Results The weight and body mass index(BMI)index of children in the obesity group were significantly higher than those in the overweight group and control group,while the weight and BMI index of children in the overweight group were significantly higher than those in the control group(P＜0.05).Serum levels of vitamin D,vitamin A,high-density lipoprotein cholesterol(HDL-C)in the obesity group were significantly lower than those in the overweight group and control group(F=63.205,14.753,1.604,P＜0.05),while fasting blood glucose(FBG),leptin,promelanocortin(POMC),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),serum total cholesterol(TC)levels were significantly higher than those in the overweight group and control group(F=79.923,1.637,23.177,46.202,93.157,293.033,P＜0.05).Children in the overweight group had higher level of glutamic oxaloacetic transaminase(AST)than control group and obesity group(F=3.919,P=0.020).Multivariate Logistic regression analysis showed that obesity was mainly related to serum vitamin A,vitamin D,leptin,POMC,FBG,HDL-C,LDL-C,TG,cholesterol.After measuring the average Gini index of factors by 100 cycles,it was found that cholesterol,FBG,leptin,TG,LDL-C,POMC,HDL-C,serum vitamin D,and vitamin A were ranked as important factors affecting the occurrence of obesity.Conclusions The relevant factors and ranking of importance influencing childhood obesity among infants and preschool children can be used as auxiliary laboratory indicators for clinical evaluation of childhood obesity.Schools and parents should reasonably distribute micro nutrients intake and adjust the dietary structure of children to avoid an increase in the rate of childhood obesity.
infants and young childrenpreschool childrenobesityvitamin Avitamin Drandom forest algorithm
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万方数据
