Correlation between serum irisin with endocrine and metabolic indicators in obese children
Objective To study the association of serum irisin level with endocrine and metabolic parameters in obese children,in order to provide reference for clinicd practice.Methods Data of 89 children treated in Linyi People's Hospital from May 2022 to May 2023 were retrospectively analyzed.According to body mass index(BMI),children were divided into obesity group(n=48)and normal control group(n=41).Multiple linear regression analysis was used to analyze the related factors of serum irisin and endocrine metabolism indexes.Results The levels of serum irisin,free triiodothyronine(FT3),free triiodothyronine/free thyroxine(FT3/FT4),thyroid stimulating hormone(TSH),adrenocoriticotropbic hormone(ACTH),triglyceride(TG),C-peptide,insulin,insulin resistance index(HOMA-IR)in obese children were significantly higher than those of the control group(t/Z=2.120,2.836,2.403,2.325,2.099,5.870,7.186,7.120,7.103,P＜0.05),while high-density lipoprotein was significantly lower than that in the control group(t=4.084,P＜0.05).It was found that serum irisin level was positively correlated with TG(r=0.390,P=0.006)and negatively correlated with FT3(r=-0.311,P=0.032).Multiple linear regression analysis showed that FT3(β=-0.468)and TG(β=0.599)were the main factors influencing serum irisin levels in obese children.Conclusion Obese children have a high serum irisin level,and irisin is associated with lipid metabolism and thyroid function.
serum irisinthyroid functionobese childrenglucose and lipid metabolism
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