儿童肥胖代谢组学的研究进展
Advances in metabolomics of childhood obesity
刘璐洁 1徐东 2尹春燕 1肖延风1
作者信息
- 1. 西安交通大学第二附属医院小儿内科,陕西西安 710004
- 2. 华中科技大学同济医学院附属同济医院儿科
- 折叠
摘要
肥胖是以脂肪积累和代谢紊乱为特征的疾病,儿童肥胖发病率日益增加,但目前体重和代谢改变背后的复杂机制尚未阐明.代谢组学是一种高通量高灵敏度的检测方法,通过对生物样本中小分子或代谢物进行全面分析和鉴定,揭示疾病和代谢之间的联系,确定潜在的生物标志物和治疗靶点,并为疾病发病机制研究提供可能线索.本文就近年来儿童肥胖代谢组学的研究进展做一概述.
Abstract
Obesity is a disease characterized by the accumulation of adipose tissue and metabolic dysregulation.The prevalence of childhood obesity is on the rise;however,the intricate mechanisms underlying changes in body weight and metabolism remain elusive.Metabolomics,a high-throughput and highly sensitive detection method,enables comprehensive analysis and identification of small molecules or metabolites in biological samples,thereky elucidating the relationship between childhood obesity and metabolism,facilitating the discovery of potential biomarkers and therapeutic targets while providing insights into the pathogenesis of childhood obesity and its associated complications.This review summarizes recent advances in metabolomics research pertaining to childhood obesity.
关键词
儿童/肥胖/代谢组学Key words
children/obesity/metabolomics引用本文复制引用
基金项目
国家自然科学基金(81673187)
西安交通大学第二附属医院科研基金(YJZD201709)
出版年
2024
NETL
NSTL
万方数据