Meta-analysis on the relationship between serum vitamin D level and nonalcoholic fatty liver disease in adolescents
Objective To systematically evaluate the correlation between vitamin D level and nonalcoholic fatty liver disease(NAFLD)in adolescents,in order to provide new ideas for the treatment of the disease.Methods The literatures regarding the correlation between NAFLD and vitamin D in adolescents from January 2013 to December 2022 were searched in PubMed,Embase,Cochrane Library,China knowledge Network and Wanfang database.Quality of the literature was evaluated by the Newcastle-Ottawa scale(NOS)and the adapted NOS quantitative change,and the Meta-analysis was carried out by Stata15.0.Results A total of 12 studies were included,including 922 adolescent NAFLD patients.Meta-analysis results showed that the level of 25(OH)D in NAFLD adolescents significantly decreased(SMD=-1.02,95％CI:-1.54--0.49,I2=96.9％).The source of heterogeneity was not found in the subgroup analysis on the type of study and the degree of national development,but the vitamin level in each subgroup decreased.Sensitivity analysis excluded each study one by one,and the results did not change in essence,suggesting that the results were stable.No obvious publication bias was found.Conclusion The level of Vitamin D is decreased in adolescent patients with NAFLD,which may be involved in the development of NAFLD.
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