The influence factors of vitamin D and its correlation with vitamin K1 and K2 in children aged 0-6 years
Objective To investigate the factors influencing vitamin D status in children aged 0-6 years and its correlation with vitamins K1 and K2,in order to provide scientific grounds for promoting the healthy development of children in this area.Methods A total of 1 447 children aged 0-6 years,who underwent pediatric health follow-ups at Jianyang Maternal and Child Health Hospital between January 2021 and December 2022,were selected as study subjects.Serum levels of 25-(OH)D,vitamin K1,and vitamin K2 were obtained through laboratory tests.The current status of vitamin D,influencing factors,and its correlations with vitamins K1 and K2 were analyzed.Results Vitamin D was found to be correlated with both vitamins K1 and K2(r=0.349-0.656,P＜0.001).Protective factors against insufficient serum 25-(OH)D levels in children aged 0-6 years included mothers being under 35 years at childbirth(OR=0.467,95％CI:0.318-0.823),mothers having education levels of junior college or above(OR=0.321,95％CI:0.253-0.373),children having a birth weight over 2 500g(OR=0.518,95％CI:0.377-0.672),and children regularly taking VD supplementation(400U/day)(OR=0.425,95％CI:0.341-0.613,P＜0.05).Conclusions Greater emphasis is needed on the regular administration of vitamin D supplements by parents,accompanied by intensified health education efforts targeting low-birth-weight infants,older mothers,and those with lower educational backgrounds.For children deficient in vitamin D,closer attention should also be paid to their serum levels of vitamins K1 and K2.
万方数据
维普
