Status quo and influencing factors of early catch-up growth in small for gestational age infants
Objective To analyze the early growth trajectory of full-term small for gestational age(SGA)infants,and to discuss the influencing factors of catch-up growth,so as to provide scientific basis for clinical management of SGA.Methods Full-term(37 weeks≤gestational age＜42 weeks)SGA infants who took physical examination and follow-up regularly in the Department of Child Health Care in the First Affiliated Hospital of Nanjing Medical University from January to December 2022 were selected in the study group.Full-term appropriate for gestational age(AGA)infants born in the same period were selected in the control group according to 1:1 match based on gestational age and gender.Z score was used to calculate growth rate and Logistic regression was used to analyze the influencing factors of catch-up growth.Results A total of 154 infants were included,including 76 SAG cases and 78 AGA cases.There were no statistical differences in gestational age,gender,delivery and feeding mode between the two groups(P＞0.05).No differences in △W AZ and△LAZ were observed between SGA and AGA at 0 months of age(t=-1.158,-1.149,P＞0.05).The growth accelerated remarkably at 1-6 months old and 7-12 months old,△W AZ and △LAZ were significantly higher than those of AGA group(t=3.114,2.494,4.170,3.587,P＜0.001).The rate of catch-up growth in SGA group was 81.6％at 12 months of age,which mainly ccurred within 6 months old when the weight growth rate was(0.71±0.16)kg/month and the length growth rate was(3.29±0.33)cm/month,significantly higher than those of the non catch-up group[(0.47±0.06)kg/month,(2.75±0.48)cm/month,t=-6.790,-2.341,P＜0.05].No difference was observed in the growth rate of body weight and length at 7-12 months of age between the two groups(P＞0.05).The proportion of boys was higher in the catch-up group and their bone mass density(BMD)Z score(-1.56±0.87)was lower than that in the non catch-up group at 6 months(0.51±1.13,t=2.071,P=0.046),while no statistical difference existed at 12 months of age(P＞0.05).Conclusions Full-term SGA infants show accelerated catch-up growth and dynamic changes in growth indicators.Catch-up growth occurrs obviously in the first 6 months after birth,more in boys and possibly results in early bone mineral deficiency.
万方数据
维普
