Role of GABAergic system in the pathogenesis and treatment of Tourette syndrome in children
Childhood Tourette syndrome(TS)is a chronic neuropsychiatric disorder with a prevalence of about 1％in children and adolescents.Its clinical features include sudden,involuntary twitching symptoms such as eye blinking,head shaking,and tics involving other muscles of the face,trunk,and limbs,as well as vocal tics.At present,the pathogenesis of TS is currently not clear,and there is no effective treatment for TS.γ-aminobotyric acid(GABA)is the primary inhibitory neurotransmitter in the mammalian brain.Some studies have shown that the imbalance of GABAergic system is involved in the occurrence and development of many neuropsychiatric diseases.In recent years,the role of GABAergic system in TS has gained much attention.Current research focuses on the abnormality of GABAergic metabolic pathway and the changes of GABA metabolism of intestinal flora in TS patients.However,there are no specific GABAergic drugs developed for the treatment of TS.This review provides insights into the role of the GABAergic system in the pathophysiology of TS and its potential as a novel therapeutic target.
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