Causal relationship between neonatalhy perbilirubinemia and tic disorder by Mendelian randomization
Objective To explore the causal relationship between neonatal hyperbilirubinemia and tic disorder(TD)by two-sample Mendelian randomized analysis(TSMR),in order to provide insights for the mechanism research of TD.Methods Data of genome-wide association study(GWAS)was used in this study.The exposure factor was neonatal hyperbilirubinemia,and the outcome variables were TD,multiple TD and vocal TD,respectively.Through MR analysis,inverse variance weighted(inverse-variance weighted,I VW)was used as the main analysis method,MR-Egger regression and weighted median(weighted median,WM)supplementary methods were used to analyze the potential relationship between them.Cochran Q test and MR-Egger regression intercept were used to analyze the sensitivity.Results The inverse variance weighting method,showed that there was a potential causal relationship between neonatal hyperbilirubinemia and the risk of TD(OR=1.053,95％CI:1.006-1.102,P=0.024),but there was no potential causal correlation with other types of TD.Sensitivity analysis showed that there was no pleiotropy and heterogeneity(P＞0.05),and the result was reliable.Conclusions There is a potential causal relationship between neonatal hyperbilirubinemia and TD,but the relationship needs to be further verified by a larger sample size.
NETL
NSTL
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