Causal relationship between gut microbiota and short stature based on genome-wide association study data
Objective To investigate the causal relationship between gut microbiota and short stature by genomewide Mendelian randomization(MR),in order to proride reference of clinical treatment of short statue.Methods Genus level gut microbiota genome-wide association study data of 18 340 samples was obtained from the MiBioGen as the exposure group,and genome-wide association study data of short stature were obtained from FinnGen R9 as the outcome group.The inverse variance weighting method was used as the main analysis method for MR analysis,and sensitivity analysis such as leave-one-out,heterogeneity test,and pleiotropy analysis were performed,reverse MR to rule out reverse causality.Results Prevotella9(OR=1.76,95％CI:1.10-2.82,P=0.018),Alloprevotella(OR=1.82,95％CI:1.22-2.72,P=0.003),and FamilyⅩⅢAD3011group(OR=1.86,95％CI:1.04-3.31,P=0.036)were positively correlated with the onset of short stature.Parasutterella(OR=0.58,95％CI:0.37-0.92,P=0.020),Clostridiumsensustricto1(OR=0.50,95％CI:0.25-0.99,P=0.045),and Roseburia(OR=0.48,95％CI:0.26-0.89,P=0.020)were negatively correlated with the onset of short stature.Conclusion Prevotella9,Alloprevotella,and FamilyⅩⅢAD3011group increase the risk of short stature,while Parasutterella,Clostridiumsensustricto1 and Roseburia have protective effects on the occurrence of short stature.
short staturegut microbiotamendelian randomizationgenome-wide association study
万方数据
维普
