The relationship between histamine and tic disorder(TD)as a neuromodulator is gradually gaining attention.Specific gene mutations of histidine decarboxylase(HDC),a key enzyme in histamine synthesis,have been discovered in TD families,verifying the hypothesis that histamine is involved in TD generation in human and animal models.Histamine and its receptors play a role in regulating cortico-striato-thalamo-cortical(CSTC)circuits,neurotransmitters,and microglia-mediated neuroinflammation,which subsequently affect the development of TD.The H3 receptor shows promise as a pharmacotherapeutic target for treating TD.This article reviews the role of histamine and its receptors in the pathogenesis of TD.
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