Influencing factors of congenital heart disease in some areas of Xinjiang Uygur Autonomous Region
Objective To analyze the prevalence and associated factors of congenital heart disease(CHD)among newborns in some areas of northern Xinjiang,China,in order to provide theoretical foundations for prevention and control strategies in the region.Methods From January 1st to December 31st,2021,145 neonates diagnosed with CHD at Altay Regional People's Hospital and Ili Prefecture Maternal and Child Health Hospital were selected as the case group.Maternal prenatal examination data and delivery records were collected through the Xinjiang Maternal and Child Health Cloud Monitoring System.Based on maternal age during pregnancy,290 healthy neonates born during the same period were matched at a ratio of 1:2 as the control group.Univariate and multivariate analysis were conducted using a case-control study design to explore the influencing factors of CHD in the Xinjiang region.Results Among the cases,patent ductus arteriosus was the most prevalent(73.10％,106 cases).Univariate analysis showed statistically significant differences in pre-pregnancy BMI,gravidity,parity,presence of anemia,Rh blood type,history of diabetes,newborn gender,gestational age,birth weight,and mode of delivery between the case and control groups(P＜0.05).Multivariate analysis revealed that pre-pregnancy overweight or obese(OR=1.919,95％CI:1.174-3.427),gravidity 2 times(2 times:OR=4.449,95％CI:2.380-8.318,≥3 times:OR=15.716,95％CI:5.680～43.487),anemia(OR=6.073,95％CI:2.193-16.813),Rh-negative blood type(OR=2.748,95％CI:1.210-11.788),history of diabetes(OR=2.463,95％CI:1.693-8.760),female newborn gender(OR=1.753,95％CI:1.141-2.694),low birth weight(OR=3.685,95％CI:1.086-12.497),macrosomia(OR=10.062,95％CI:2.667-37.959),and cesarean delivery(OR=2.491,95％CI:1.515-4.097)were risk factors for CHD(P＜0.05).Full-term neonates served as a protective factor(OR=0.484,95％CI:0.272-0.861)against CHD(P＜0.05).Conclusions CHD is associated with pre-pregnancy BMI,gravidity,history of diabetes,anemia,birth weight,gestational age,and mode of delivery.Pre-pregnancy testing and genetic counseling services should be strongly promoted to reduce the incidence of CHD.
万方数据
维普
