Risk factors for high-risk human papillomavirus infection and the influence on vaginal microbiota
Objective To investigate the risk factors for high-risk human papillomavirus(HR-HPV)infection,and the influence on vaginal microbiota.Methods We conducted a retrospective analysis of clinical data from 112 patients diagnosed with HR-HPV infection who were admitted to the Fifth Affiliated Hospital of Zhengzhou University between December 2018 and December 2022.Additionally,83 normal women were selected as the control group.We analyzed the types and risk factors of HR-HPV infection,and explore the alterations in vaginal microenvironment following HR-HPV infection.Results In the HR-HPV group,there were 70 cases of single infection and 42 cases of multiple infections.Univariate analysis and logistic regression analysis found that age of the first sexual life＜18 years,gravidity ≥ 5 times,frequency of sexual life ≥ 5 times/month and times of abortion ≥ twice were independent risk factors for persistent HR-HPV infection.Conversely,using condoms for contraception and practicing post-sexual hygiene were found to be protective factors(P＜0.05).The prevalence of bacterial vaginosis(BV)in patients with multiple infection was significantly higher at 21.43％compared to 9.52％in patients with single infection(P＜0.05).Conclusion The age of first sexual activity,number of pregnancies,frequency of sexual activity,history of miscarriages,contraception methods,and post-sexual cleaning behavior are the influencing factors for HR-HPV infection.Furthermore,HR-HPV infection can adversely affect the vaginal microecological environment.
high-risk human papillomavirusvaginal microbiotarisk factor
NETL
NSTL
万方数据
维普
