高危型人乳头瘤病毒感染的危险因素及对阴道微生态环境的影响
Risk factors for high-risk human papillomavirus infection and the influence on vaginal microbiota
符元元 1顾晓荔 1田树轩 1孟跃进1
作者信息
- 1. 郑州大学第五附属医院宫腔镜诊疗部,河南郑州 450052
- 折叠
摘要
目的 探讨高危型人乳头瘤病毒(HR-HPV)感染的危险因素及对阴道微生态环境的影响.方法 回顾性分析2018年12月至2022年12月郑州大学第五附属医院收治的112例HR-HPV感染患者的临床资料,设为HR-HPV组,对感染型别进行分析,另取同期在本院行妇科体检的83例正常女性为对照组.分析HR-HPV感染的型别与危险因素,并探讨HR-HPV感染后阴道微生态环境变化.结果 HR-HPV组中,单一感染70例,多重感染42例;单因素与Logistic回归分析发现初次性生活年龄＜18岁、妊娠次数≥5次、性生活频率≥5次/月、流产次数≥2次为HR-HPV感染的独立危险因素,避孕套避孕、性生活后清洗行为是保护因素(P＜0.05).HR-HPV多重感染BV检出率21.43％明显高于单一感染者9.52％(P＜0.05).结论 初次性生活年龄、妊娠次数、性生活频率、流产次数、避孕、性生活后清洗行为情况为HR-HPV感染影响因素,且HR-HPV感染可影响阴道微生态环境.
Abstract
Objective To investigate the risk factors for high-risk human papillomavirus(HR-HPV)infection,and the influence on vaginal microbiota.Methods We conducted a retrospective analysis of clinical data from 112 patients diagnosed with HR-HPV infection who were admitted to the Fifth Affiliated Hospital of Zhengzhou University between December 2018 and December 2022.Additionally,83 normal women were selected as the control group.We analyzed the types and risk factors of HR-HPV infection,and explore the alterations in vaginal microenvironment following HR-HPV infection.Results In the HR-HPV group,there were 70 cases of single infection and 42 cases of multiple infections.Univariate analysis and logistic regression analysis found that age of the first sexual life＜18 years,gravidity ≥ 5 times,frequency of sexual life ≥ 5 times/month and times of abortion ≥ twice were independent risk factors for persistent HR-HPV infection.Conversely,using condoms for contraception and practicing post-sexual hygiene were found to be protective factors(P＜0.05).The prevalence of bacterial vaginosis(BV)in patients with multiple infection was significantly higher at 21.43％compared to 9.52％in patients with single infection(P＜0.05).Conclusion The age of first sexual activity,number of pregnancies,frequency of sexual activity,history of miscarriages,contraception methods,and post-sexual cleaning behavior are the influencing factors for HR-HPV infection.Furthermore,HR-HPV infection can adversely affect the vaginal microecological environment.
关键词
高危型人乳头瘤病毒/阴道微生态环境/危险因素Key words
high-risk human papillomavirus/vaginal microbiota/risk factor引用本文复制引用
基金项目
河南省科技计划(2021)(212102310466)
出版年
2024
NETL
NSTL
维普
万方数据