The value of HPV L1 capsid protein combined with high-risk HPV typing,CA125,SCC-Ag in the diagnosis of cervical cancer
Objective To explore the value of human papillomavirus(HPV)L1 capsid protein combined with HPV typing,carbohydrate antigen 125(CA125)and squamous cell carcinoma antigen(SCC-Ag)in the diagnosis of cervical cancer.Methods A total of 214 patients with cervical lesions who were treated in our hospital from January 2021 to December 2022 were selected,including 45 patients with cervical cancer,56 patients with high cervical intraepithelial neoplasia(CIN)lesions(CIN Ⅱ and CIN Ⅲ),47 patients with low CIN lesions(CIN Ⅰ),and 66 patients with cervicitis.We analyzed the differences in HPV L1 capsid protein,high-risk HPV typing,serum CA125 and SCC-A.Results The positive rate of HPV L1 in low-grade CIN group was significantly higher than that in other patients(P＜0.05).The positive rates of HPV L1 in cervicitis and high-grade CIN were significantly higher than those in cervical cancer(P＜0.05).With the severity of cervical lesions,the positive rate of high-risk HPV increased significantly(P＜0.05).Serum CA125 and SCC-Ag levels also significantly increased with worsening cervical lesions(P＜0.05).The area under the Receiver operating characteristic curve for the diagnosis of cervical cancer using HPV L1 capsid protein with high-risk HPV typing,CA125,SCC-Ag diagnosis was 0.630,indicating low diagnostic value.Conclusions HPV L1 capsid protein,high-risk HPV typing,serum CA125 and SCC-Ag showed significant differences among patients with different cervical diseases.Among these markers,high-risk HPV typing and serum CA125 displayed certain diagnostic value in the diagnosis of cervical cancer,while HPV L1 capsid protein combined with high-risk HPV typing,CA125 and SCC-Ag had limited diagnostic value for cervical cancer.
NETL
NSTL
万方数据
维普
