Clinical efficacy analysis of thinprep cytologic test,high-risk human papillomavirus and p16/Ki-67 dual-staining in the diagnosis of cervical lesions
Objective To investigate the clinical efficacy of thinprep cytologic test(TCT),high-risk human papillomavirus(HPV)test and p16/Ki-67 dual-staining in the diagnosis of cervical lesions.Methods Clinical data of 411 women with cervical cancer screening were retrospectively analyzed between January 2018 and June 2022 in the First People's Hospital of Jiande City and were examined by TCT,HPV test,and p16/Ki-67 dual-staining to analyze the correlation between detection results of above three tests,and to further evaluate the clinical efficacy of the three tests alone and in combination for the diagnosis of high-grade squamous intraepithelial lesions(HSIL)and above.Results There were significant differences in the positive rates of p16/Ki-67 dual-staining among TCT subgroups,HPV subgroups and histopathological diagnostic subgroups(P＜0.05).The positive rate of p16/Ki-67 dual-staining in the HSIL and cervical squamous cell carcinoma subgroups was significantly higher than the other subgroups(P＜0.05).The positive rate of p16/Ki-67 dual-staining in subtype 16/18 subgroup was significantly higher than the other 12 subtype positive subgroup and negative subgroup(P＜0.05).The positive rate of p16/Ki-67 dual-staining in HSIL and cervical squamous cell carcinoma subgroups was significantly higher than the other subgroups(P＜0.05).Spearman correlation analysis showed that the positive rate of p16/Ki-67 dual-staining was positively correlated with the results of TCT and HPV detection(P＜0.05).There were significant differences in the clinical efficacy of thinprep cytologic test,HPV and p16/Ki-67dual-staining alone and in combination in the diagnosis of HSIL+and above by histopathological diagnosis as gold standard(P＜0.05).The combined sensitivity of the three methods was the highest,and p16/Ki-67 dual-staining possess the highest Yoden index.Conclusion The results of p 16/Ki-67 dual-staining of cervical lesions were correlated with the results of cytology and high-risk HPV diagnosis and the combination of above three methods had the highest sensitivity in the diagnosis of HSIL and above,and p 16/Ki-67 dual-staining had the best comprehensive diagnostic efficacy.
NETL
NSTL
万方数据
维普
