Study on influencing factors and predictive efficacy of lymph vascular space invasion in patients with endometrial carcinoma
Objective To investigate the influencing factors and predictive efficacy of lymph vascular space invasion(LVSI)in patients with endometrial carcinoma to provide more evidence for early identification of high-risk groups of LVSI and guidance for the formulation of surgical protocols.Methods We retrospectively analyzed data from 277 patients with endometrial carcinoma between January 2015 and December 2022.Patients were divided into infiltrated group(60 cases)and non-infiltrated group(217 cases)according to the presence or absence of LVSI.The clinicopathologic characteristics of two groups were compared,and the independent influencing factors of LVSI in patients with endometrial cancer were evaluated by multivariate Logistic regression model.The ROC curve was used to evaluate the clinical efficacy of independent factors above in predicting of the LVSI risk in patients with endometrial cancer.Results There were 60 cases with LVSI in 277 patients with the incidence of 21.66％.There were statistically significant differences in preoperative CA125 level,maximum diameter,histopathological type,histopathological grade,depth of muscular infiltration,proportion of cervical muscular infiltration and proportion of lymph node metastasis between the two groups(P＜0.05).Multivariate logistic regression analysis showed that the depth of muscle infiltration,histopathological type and histological grade were independent factors influencing the occurrence of LVSI in patients with endometrial cancer(P＜0.05).ROC curve analysis results showed that the depth of muscle infiltration,histopathological type and histological grade could be used to predict the LVSI risk in patients with endometrial cancer,and the combination of three indexes above was better than two indexes above combination and single factors(P＜0.05).Conclusions Lymph vascular space invasion in patients with endometrial carcinoma is related to the depth of muscle infiltration,histopathological type and histological grade.Patients with muscular infiltration depth ≥ 1/2,non-endometrioid adenocarcinoma and poorly differentiated carcinoma have the higher risk of lymph vascular space invasion.
endometrial cancerlymph vascular space invasioninfluence factorpredict
NETL
NSTL
万方数据
维普
