The clinical efficacy of topical Nocardia rubra cell wall skeleton in the treatment of high-risk HPV persistent infection with or without LSIL:a prospectively study
Objective To prospectively estimate the clinical efficacy of topical Nocardia rubra cell wall skeleton(Nr-CWS)in the treatment of high-risk HPV persistent infection with or without LSIL.Methods From January 2018 to March 2020,108 subjects with HR-HPV persistently infected for 12 months or more with or without LSIL who visited in The First Affiliated Hospital of Zhengzhou University were selected and randomly divided into 2 groups according to the ratio of 3∶1.The test group(81 cases)was given Nr-CWS by topical,and the control group(27 cases)was treated with placebo.A total of 94 cases were followed up,including 68 cases in test group and 26 cases in control group.The efficacy of the two groups was compared at 1,4,8 and 12 months after treatment,through HPV negative conversion,and the occurrence of adverse reactions between the two groups were compared.Results One month after treatment,the effective rate of the test group and the control group was 19.12％(13/68)and 3.85％(1/26),respectively,and there was no statistical significance between the two groups(P＞0.05).At 4,8 and 12 months after treatment,the effective rates of the test group were 54.41％(37/68),72.06％(49/68),82.35％(56/68),and the control group were 23.08％(6/26),38.46％(10/26),38.46％(10/26),respectively.The difference between the two groups was statistically significant(P＜0.05).In the study group,12 months after treatment,the effective rates of HPV16,HPV18 and non-HPV16/18 were 82.61％(19/23),62.50％(5/8)and 84.21％(32/38),respectively,and there was no statistical significance among the three groups(P＞0.05).The effective rates of HR-HPV persistent infection with LSIL and HR-HPV persistent infection without LSIL were 85.19％(23/27)and 80.49％(33/41),respectively,with no statistical significance(P＞0.05).The incidence of adverse reactions including increased secretions was 8.82％(6/68)and 7.69％(2/26)in the test group and the control group,respectively,with no statistical significance(P＞0.05).Conclusions Nr-CWS is effective in the treatment of persistent HR-HPV infection,and it is also effective in the treatment of persistent HR-HPV infection with LSIL.
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