Changes of serum BNP and left ventricular function in late pregnancy of pregnant women with severe preeclampsia
Objective To investigate the changes of serum brain natriuretic peptide(BNP)and left ventricular function in late pregnancy of pregnant women with severe preeclampsia(sPE).Methods A retrospective analysis was conducted on the clinical and ultrasound data of 112 sPE patients admitted to the Jinjiang Maternity and Child Health Hospital of Chengdu from January 2021 to January 2023.Patients were divided into early onset group(43 cases)and late onset group(69 cases)based on the onset time.The serum BNP and left ventricular structure and functional parameters.Results The serum BNP in the early onset group was significantly higher than that in the late onset group(P＜0.05).The E/A and e'/s'of the early onset group were significantly lower than those of the late onset group,while IVRT and LAVI were significantly higher than those of the late onset group(P＜0.05),but there was no statistically significant difference in other indicators between the two groups(P＞0.05).Pearson correlation analysis showed that serum BNP level was negatively correlated with E/A and e'/s'(r=-0.381,-0.273,P＜0.05),and significantly positively correlated with LVAI and IVRT(r=0.271,0.258,P＜0.05).Conclusion Compared with late onset sPE patients,left ventricular diastolic function is inclined to decrease in early onset sPE patients,and the increase of serum BNP levels can reflect the patient's left ventricular diastolic function reduction to some extent.
pregnancysevere preeclampsiabrain natriuretic peptideultrasoundleft ventricular function
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