目的 本研究旨在探讨观察卵磷脂对妊娠期肝内胆汁淤积症患者SOCS-3及ET-1的影响。方法 以温州医科大学附属平阳医院2020年2月至2022年1月收治入院的妊娠期肝内胆汁淤积症患者106例为研究对象，随机分为对照组和研究组各53例，分别给予熊去氧胆酸片治疗及联合卵磷脂治疗。对比治疗前后两组瘙痒评分、肝功能、SOCS-3及ET-1水平，统计治疗后两组瘙痒及黄疸消失时间及母婴结局。结果 治疗前，两组瘙痒评分比较差异无统计学意义(P＞0。05);治疗后，与对照组瘙痒评分、瘙痒及黄疸消失时间相比，研究组更低(P＜0。05)。治疗前，两组TPB、AST、ALT比较差异均无统计学意义(P＞0。05);治疗后，与对照组TPB、AST、ALT相比，研究组更低(P＜0。05)。治疗前，两组SOCS-3及ET-1比较差异均无统计学意义(P＞0。05);治疗后，与对照组SOCS-3及ET-1相比，研究组更低(P＜0。05)。治疗后，研究组顺产率及5 min Apgar评分均高于对照组(P＜0。05);与对照组早产、妊娠高血压、胎膜早破、新生儿窘迫、羊水污染、围产儿死亡发生率相比，研究组更低，但差异均无统计学意义(P＞0。05)。结论 卵磷脂能够有效地促使妊娠期肝内胆汁淤积症患者肝功能恢复正常，改善母婴结局，值得临床推广应用。
Effect of lecithin on SOCS-3 and ET-1 in patients with intrahepatic cholestasis of pregnancy
Objective To investigate the effects of lecithin on SOCS-3 and ET-1 in patients with intrahepatic cholestasis of pregnancy.Methods A total of 106 patients with intrahepatic cholestasis of pregnancy admitted to Pingyang Hospital Affiliated to Wenzhou Medical University from February 2020 to January 2022 were selected as the study objects.By using random number table method,they were divided into control group and study group,with 53 cases,respectively,receiving ursodeoxycholic acid tablets and combined lecithoid therapy.Pruritus score,liver function,SOCS 3 and ET-1 levels were compared between the two groups before and after treatment.The time of pruritus and jaundice disappearing after treatment and the outcome of mother and child were analyzed.Results Before treatment,the itch scores of the two groups were compared,there was no statistically significant difference(P＞0.05).After treatment,itchiness score,itchiness and jaundice disappearance time were lower in the study group than in the control group(P＜0.05).Before treatment,TPB,AST and ALT were compared between the two groups,there were no statistically significant differences(P＞0.05).After treatment,TPB,AST and ALT in the study group were lower than those in the control group(P＜0.05).Before treatment,SOCS-3 and ET-1 were compared between the two groups,there were no statistically significant differences(P＞0.05).After treatment,the levels of SOCS-3 and ET-1 in the study group were lower than those in the control group(P＜0.05).After treatment,the vaginal delivery rate and 5-minute Apgar score in the study group was higher than the control group(P＜0.05);Preterm birth,gestational hypertension,premature rupture of membranes,neonatal distress,amniotic fluid contamination and perinatal death were lower in the study group than in the control group,but there were no statistically significant differences(P＞0.05).Conclusion Lecithin can effectively restore liver function to normal in patients with intrahepatic cholestasis of pregnancy,improve maternal and infant outcomes,and is worthy of clinical application.
lecithinIntrahepatic cholestasis of pregnancymaternal and infant outcome
NETL
NSTL
万方数据
