Comparison of intervention effect of weight loss therapy and drug therapy on patients with overweight/obese PCOS
Objective To compare the efficacy of weight loss therapy and drug therapy(Yousiyue combined with metformin)on obese polycystic ovary syndrome(PCOS).Methods A total of 106 patients with overweight/obese PCOS admitted to Huainan Maternal and Child Health Hospital from January 2022 to October 2022 were included and randomly divided into weight loss group(n=53)and drug group(n=53).The weight loss group was treated with weight loss therapy,and the drug group was given Yousiyue combined with metformin.Both groups were treated for 3 months.BMI,PCOS sign score,insulin-related indicators,sex hormones indicators and glucolipid metabolism indicators before and after treatment and pregnancy rate and adverse reactions were compared.Results The baseline data revealed no statistically significant differences between both groups(P＞0.05).After treatment,the BMI,waist circumference,PCOS sign score,and levels of TC and TG in both groups were significantly decreased(P＜0.05),and the BMI,waist circumference,TC and TG in weight loss group were lower than those in drug group(P＜0.05).After 3 cycles of treatment,the HOMA-IR,AMH and T in drug group were significantly lower compared with those in weight loss group(P＜0.05),but there were no obvious differences in other indicators(FINS,HOMA-β,LH,E2,and FPG)between groups(P＞0.05).During follow-up,there were no statistical differences in the biochemical pregnancy rate and clinical pregnancy rate between the two groups(P＞0.05).Conclusions Weight loss therapy has the same efficacy as Yousiyue combined with metformin on patients with obese PCOS,and both therapies can effectively improve the insulin resistance,hormone disorder and glucolipid metabolism imbalance,and enhance the clinical pregnancy rate.However,weight loss therapy is healthier and safer.
obesity-related polycystic ovary syndromeweight loss therapyyousiyuemetformin
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