上皮性卵巢癌中Siglec-15表达水平与其预后的关系
The expression of Siglec-15 in epithelial ovarian cancer and its relationship with prognosis
王敏 1邱海峰 1严淑萍 2石晓静 3金玉茜1
作者信息
- 1. 郑州大学第一附属医院妇科,郑州 450000
- 2. 郑州大学第一附属医院病理科,郑州 450000
- 3. 郑州大学医学科学院,郑州 450002
- 折叠
摘要
目的 探讨唾液酸结合免疫球蛋白样凝集素15(Siglec-15)在上皮性卵巢癌中的表达及其与患者预后的关系.方法 采用免疫组织化学染色(SABC法)检测123例(67.21％)上皮性卵巢癌及60例(32.79％)正常卵巢组织中Siglec-15的表达水平,以平均光密度表示,通过Kaplan-Meier法分析其与患者生存期的相关性.采用Pearson相关性分析Siglec-15及程序性细胞死亡1(PD-L1)表达的相关性,并分析Siglec-15的表达与卵巢癌临床病理特征的关系.结果 Siglec-15在上皮性卵巢癌中的表达水平(55.28％,68/123)较正常卵巢组织(6.67％,4/60)显著升高(x2=39.943,P=0.000).Siglec-15高表达与组织类型、淋巴结转移可能相关(x2=3.373,P=0.066;x2=3.172,P=0.075);Siglec-15与年龄、2014年FIGO分期和肿瘤大小不相关(P均＞0.05);生存分析显示,Siglec-15表达水平与上皮性卵巢癌患者的总生存期及无进展生存期均无明显相关性(P均＞0.05);Pearson相关性分析显示,Siglec-15表达水平与PD-L1表达水平无相关性(r=0.038,P=0.682).结论 Siglec-15在上皮性卵巢癌中表达水平显著升高,可能是一个新的治疗靶点.
Abstract
Objective To investigate the expression of sialic acid-binding immunoglobulin-like lectin 15(Siglec-15)in epithelial ovarian cancer and its relationship with prognosis.Methods The expression level of Siglec-15 in 123 cases(67.21％)of epithelial ovarian cancer and 60 cases(32.79％)of normal ovarian tissue were detected by immunohistochemistry(SABC).The expression was expressed by mean optical density,and the correlation between SIGLEC-15 and survival was analyzed by Kaplan-Meier.Pearson correlation was used to analyze the correlation between Siglec-15 and programmed cell death 1 ligand 1(PD-L1)expression and the relationship between Siglec-15 expression and clinicopathological features of ovarian cancer.Results The expression level of Siglec-15 in epithelial ovarian cancer tissues(55.28％,68/123)was significantly higher than that in normal ovary(6.67％,4/60)(x2=39.943,P=0.000).The high expression of Siglec-15 was correlated with tissue type and lymph node metastasis(x2=3.373,P=0.066;x2=3.172,P=0.075).Siglec-15 was not associated with age,2014 FIGO stage or tumor size(all P＞0.05).There was no significant correlation between Siglec-15 and overall survival and progression free survival of epithelial ovarian cancer patients(all P＞0.05).Pearson correlation analysis showed that there was no correlation between the expression levels of Siglec-15 and PD-L1(r=0.038,P=0.682).Conclusions The expression level of Siglec-15 is significantly increased in epithelial ovarian cancer,which may be a new therapeutic target.
关键词
上皮性卵巢癌/唾液酸结合免疫球蛋白样凝集素15/靶向程序性细胞死亡1/总生存期/无进展生存期Key words
epithelial ovarian cancer/sialic acid-binding immunoglobulin-like lectin 15/programmed cell death 1 ligand 1/overall survival/progression free survival引用本文复制引用
出版年
2024
NETL
NSTL
万方数据