Objective To explore the correlation between vaginal flora and cervical flora and cervical squamous intraepithelial lesion(SIL)in women with HR-HPV infection.Methods A total of 700 HR-HPV-infected women from Qingdao Haici Hospital affiliated with Qingdao University(Qingdao Hospital of Traditional Chinese Medicine)were selected as the study group,and 420 HPV-negative physical examination data during the same period were selected as the control group.The distribution of vaginal and cervical microflora in the study group and the control group were compared,and the patients in the study group were divided into SIL group(n=278)and non-SIL group(n=422)according to whether SIL occurred.Vaginal and cervical microflora distribution and microflora microecology were compared between SIL group and non-SIL group,and the correlation between vaginal microecology of HR-HPV infected women and HR-HPV infection and SIL was analyzed.Results The negative rate of vaginal and cervical lactobacilli,the infection rate of bacteria and mycoplasma in the study group were significantly higher than those in the control group(P＜0.05).The proportion of vaginal and cervical lactobacilli negative and bacterial infection in SIL group was significantly higher than that in non-SIL group(P＜0.05).The normal rate of colony density,the normal rate of bacterial diversity,the proportion of lactic acid bacteria as the dominant bacteria,the proportion of pH ≤ 4.5,the proportion of sialidase negative and the proportion of leucocyte esterase negative in SIL group were significantly lower than those in non-SIL group(P＜0.05),and the vaginal Nugent score was significantly higher than that in non-SIL group(P＜0.05).The proportion of normal colony density,normal flora diversity and negative leukocyte esterase in LSIL group was significantly higher than that in HSIL group(P＜0.05).The vaginal Nugent score was significantly lower than that in the HSIL group(P＜0.05).Spearman correlation coefficient analysis showed that the vaginal Nugent score of women with HR-HPV infection was significantly positively correlated with HR-HPV infection and SIL(P＜0.05).Conclusion The vaginal flora and cervical flora of women with high-risk HPV infection have pathogenic microbial infection and microecological imbalance,and the microecology of vaginal flora are significantly correlated with SIL.
关键词
人乳头瘤病毒/阴道菌群/子宫颈菌群/鳞状上皮内瘤变/相关性
Key words
human papillomavirus/vaginal flora/cervical flora/squamous intraepithelial lesion/correlation
维普
万方数据