Effects of percutaneous acupoint electrical stimulation combined with propofol intravenous anesthesia after ovarian cancer surgery
Objective To investigate the effects of percutaneous acupoint electrical stimulation combined with propofol intravenous anesthesia on serum glial fibrillary acidic protein(GFAP),S100 calcium-binding protein(S100 calcium-binding protein)levels,oxidative stress and immune function.Methods A total of 90 patients who underwent laparoscopic radical resection of ovarian cancer in our hospital were selected as research objects,and were divided into control group and observation group with 45 cases in each group according to random number table method.The control group was given intravenous infusion of propofol to maintain anesthesia,and the observation group was given acupoint electrical stimulation 20 minutes before induction of intravenous anesthesia.The effect of anesthesia was evaluated after surgery.Fasting venous blood was collected from all patients 1 day before surgery,1 day after surgery,and 3 days after surgery to detect GFAP,S100β protein,malondialdehyde(MDA),and super oxide dismutase(SOD)levels and CD3+,CD4+and CD4+/CD8+levels.Results In observation group,the total effective rate of anesthesia was statistically higher than that in control group(P＜0.05).No significant differences were found in serum levels of GFAP,S100β protein,MDA,SOD,CD3+,CD4+,CD8+and CD4+/CD8+between the two groups before surgery(P＞0.05).In the observation group,serum levels of GFAP,S100β protein and MDA were statistically lower than those in the control group 1 day and 3 day after surgery(P＜0.05).The level of SOD exhibited a significant increase compared to the control group(P＜0.05).Both in observation group and control group,compared with before surgery,the levels of serum GFAP,S100β protein and CD8+were statistically increased,while the levels of CD3+,CD4+and CD4+/CD8+were significantly decreased one day after surgery(P＜0.05).Compared with 1 day after surgery,SOD,CD3+,CD4+and CD4+/CD8+levels in observation group and control group were significantly increased,while serum GFAP,S100β protein,MDA and CD8+levels were significantly decreased(P＜0.05).Conclusion Compared with intravenous anesthesia with propofol alone,combined with percutaneous acupoint electrical stimulation has better anesthetic effect on radical operation of ovarian cancer,and has less effect on serum GFAP,S100βprotein levels,oxidative stress response and immune suppression in perioperative period.
percutaneous acupoint electrical stimulationpropofolovarian canceroxidative stressimmune function
万方数据
维普
