Effect of recombinant human growth hormone on early onset LH peak and clinical pregnancy outcomes in ovarian reserve
Objective To explore the effects of recombinant human growth hormone(rhGH)on early onset LH peak and clinical pregnancy outcome in patients with diminished ovarian reserve function.Methods A retrospective analysis was performed on 137 patients with decreased ovarian reserve who underwent in vitro fertilization-embryo transfer(IVF-ET)in the Obsterics and Gynecology Department of our hospital from March 2021 to May 2022.Among them,the patients treated with rhGH combined with antagonist regimen were rhGH group(n=86),and the patients treated only with antagonist regimen were in the control group(n=51).Ovulation related indexes,laboratory indexes and clinical pregnancy outcomes of patients with reduced ovarian reserve were compared between the two groups.Results There was no significant difference in the days of Gn use,follicle number of hCG day and P value of hCG day between rhGH(P＞0.05),but the total Gn and LH value of hCG day in rhGH were significantly lower(P＜0.05).The intima thickness and E2 value of hCG day were higher(P＜0.05).The high quality embryo rate and number of high-quality embryos in rhGH noticeably higher than those(P＜0.05),and the peak rate and embryo rate of unusable early onset LH were noticeable(P＜0.05).The average number of transplanted embryos,pregnancy rate of rhGH had no statistical significance(P＞0.05),but the embryo implantation rate of rhGH was noticeably higher(P＜0.05).Conclusions In IVF-ET treatment,adding rhGH can effectively reduce LH peak rate,improve high-quality embryo rate and embryo implantation rate,thereby obtaining higher-quality embryos and embryo implantation rate.
万方数据
维普
