目的 探讨胚胎移植日不同阴道彩色多普勒超声子宫内膜容受性参数与冻融胚胎移植(frozen-thawed embryo transfer，FET)患者临床结局的关系。方法 选取179例全胚冷冻后第一次FET患者，在胚胎移植日行经阴道彩色多普勒超声，检测子宫内膜厚度、容积、子宫内膜血流及双侧子宫动脉血流，按照临床结局分为妊娠组(89例)和非妊娠组(90例)，比较两组不同参数与FET临床妊娠结局的关联。结果 两组间年龄和双侧子宫动脉搏动指数(PI)比较，差异有统计学意义(P＜0。05)，且不同PI水平的FET妊娠结局比较，差异有统计学意义(P＜0。05)，左侧子宫动脉PI ≥ 3。59组患者未妊娠，右侧子宫动脉PI ≥ 2。91组患者临床妊娠率与右侧子宫动脉PI＜2。91组比较显著下降(23。3％，54。4％;P=0。002)。多因素logistic回归分析显示，年龄及左、右侧子宫动脉 PI 对 FET 临床结局影响的 OR 值分别为 0。911(95％CI:0。855～0。971)、0。715(95％CI:0。566～0。904)和0。384(95％CI:0。244～0。695)，调整年龄后分别为 0。707(95％CI:0。522～0。905)和 0。398(95％CI:0。251～0。630)。结论 双侧子宫动脉PI是FET临床结局的独立影响因素。
Clinical outcomes of frozen-thawed embryo transfer patients after whole embryo freezing with different endometrial receptivity parameters via vaginal color Doppler ultrasound
Objective To investigate the relationship between different endometrial receptivity parameters of vaginal color Doppler ultrasound on the day of embryo transfer and the clinical outcomes of frozen-thawed embryo transfer(FET).Methods The endometrial thickness,volume,endometrial blood flow and bilateral uterine artery blood flow parameters were detected by transvaginal color Doppler ultrasound on the day of embryo transfer.According to the clinical outcome,the patients were divided into pregnant group(89 cases)and non-pregnant group(90 cases),and the correlation between different parameters and clinical pregnancy outcomes of FET was compared between the two groups.Results The differences were statistically significant(P＜0.05)in age and bilateral uterine artery PI between the two groups.The differences of pregnancy rate of FET with different PI levels were statistically significant(P＜0.05).There was no clinical pregnancy in the left uterine artery PI ≥ 3.59 group.The clinical pregnancy rate in the right uterine artery PI ≥ 2.91 group was significantly lower than that in the right uterine artery PI＜2.91 group(23.3％,54.4％,P=0.002).Multivariate logistic regression analysis showed that the OR values of age,left and right uterine artery PI on clinical outcomes of FET were 0.911(95％CI:0.855～0.971)and 0.715(95％CI:0.566～0.904)and 0.384(95％CI:0.244～0.695),respectively.After adjusted age,left and right uterine artery PI on clinical outcomes of FET were 0.707(95％CI:0.522～0.905)and 0.398(95％CI:0.251～0.630),respectively.Conclusions The PI of bilateral uterine arteries is an independent influencing factor for the clinical outcome of FET.
万方数据
维普
