Analysis of risk factors and perinatal outcomes of twin pregnancies complicated with gestational diabetes mellitus
Objective To investigate the risk factors and perinatal outcomes of twin pregnancies complicated with GDM.Methods A retrospective analysis was conducted on the clinical data of 383 twin pregnant women who delivered at Wuhan University People's Hospital from January 2021 to December 2022,including 82 cases in the GDM group(the research group)and 301 cases in the group with normal glucose tolerance(the control group)The general clinical characteristics,perinatal outcomes of the two groups and the risk factors of GDM were analyzed.Results Compared with the control group,the ratios of advanced pregnancy 41.5％,overweight/obesity before pregnancy 35.4％,history of PCOS 13.4％,assisted reproductive technology 75.6％were higher in the study group[(Respectively:17.9％,19.9％,6.3％,59.1％)(178/301)](P＜0.05);The incidences of premature rupture of membranes 15.9％,postpartum hemorrhage 3.7％,gestational hypertension 7.3％,preeclampsia 20.7％,intrahepatic cholestasis of pregnancy 17.1％in the study group were higher(Respectively:3.3％,0.7％,0.7％,1.0％,2.7％)(P＜0.05);The average birth weight[(2 385.5±504.4)g],the incidence of LGA in any neonates 30.5％in the study group were higher[Respectively:(2 278.8±535.4)g,17.9％(54/301)](P＜0.05).Advanced age(P=0.022),pre-pregnancy BMI(P=0.008),assisted reproductive conception(P=0.009),PCOS history(P=0.032)and weight gain(P=0.001)during pregnancy were independent risk factors for twin pregnancies complicated with GDM.Conclusions Twin pregnancies complicated with GDM increase the incidence of preeclampsia,gestational hypertension,postpartum hemorrhage and other adverse maternal outcomes,but there are limited impacts on neonatal outcomes.Advanced age,pre-pregnancy BMI,assisted reproductive technology and PCOS history increase the risk of GDM.
万方数据
维普
