Objective To explore the correlation between the expression of Beclin-1 and P62 in placental tissue and the perinatal outcomes of late-onset preeclampsia patients.Methods A retrospective study was conducted to collect data from 186 patients with late-onset preeclampsia who completed delivery in hospitals from January 2021 to December 2023.According to the occurrence of adverse outcomes in the perinatal period,they were divided into a poor outcome group(n=45)and a good outcome group(n=141).The relative expression of Beclin-1 and P62 in placental tissues and other general data were compared between the two groups.The correlation between the relative expression of Beclin-1 and P62 in the disc tissue and the perinatal outcome of patients with late-onset preeclampsia was analyzed utilizing Logistic regression model and restricted cubic spline method.Results The relative expression level of Beclin-1 in placental tissue of the poor outcome group was higher than that of the good outcome group,and the relative expression level of P62 was lower than that of the good outcome group(P＜0.05).The proportion of severe disease severity in the poor outcome group was higher than that in good outcome group(P＜0.05).Logistic regression analysis showed that the perinatal outcomes of late--onset preeclampsia patients were related to the expression of Beclin-1 and P62 in placental tissue and the severity of the disease(P＜0.05).The results of the restricted cubic spline method analysis showed that the risk of adverse perinatal outcomes in late-onset preeclampsia patients was linearly dose-response related to the expression levels of Beclin-1 and P62 in placental tissue(P＜0.05).Conclusions The perinatal outcomes of late-onset preeclampsia patients may be related to the expression of Beclin-1 and P62 in placental tissue.
维普
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