[Purpose/significance]From the perspective of bidirectional mapping of classification systems,exploring the interactive characteristics and patterns between science and technology can help to detect technological opportunities,measure innovation levels,understand the relationship between industry,academia,and government,and build a high-quality roadmap.[Method/process]Based on the DrugBank database,academic inventors are used as a bridge to collect the following information:academic papers,patents,byline institutions,MeSH headings,and IPC codes.Science/technology tag is assigned for each byline institution on the basis of its research/development property.Then,a bidirectional mapping between MeSH headings and IPC codes is constructed.Finally,the characteristics and patterns of science-technology interactions in the biopharmaceutical field are analyzed.[Result/conclusion]In the field of biopharmaceuticals,the knowledge flow from technology to science is obviously higher than that from science to technology;Scientific research on young people has propelled the technological development of oxygen,sulfur,and the physical shape of drugs.In the interaction between science and technology,MeSH headings about males are higher than that about females.The MeSH headings about animals,humans of different age groups,and the IPC codes"A61K 45/06"and"A61P 43/00"dominate knowledge units in science-technology interaction.Several active scientific theories in the interactions between science and technology include Dose-Response Relationship,Virus Replication,Remission Induction and so on,which play a supporting role in the research of patented technologies related to"A61K 31/52".Similarly,several most active patented technologies in the science-technology interactions are"A61K 45/06","A61K 9/00",and so forth,which are relevant to anti-inflammatory drugs,cardiac stimulants,anti-tumor drugs,and other drugs.They have received widespread attention from the public and have a high potential demand.
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