利用胞质分裂阻断微核法分析394名放射工作人员微核率
Analysis of micronucleus rate in 394 radiation workers with cytokinesis-block micronucleus method
刘海翔 1赵骅 2高宇 3张杰 1张学清 1夏颖1
作者信息
- 1. 北京核工业医院体检中心,北京 100045
- 2. 中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室,北京 100088
- 3. 河南省第三人民医院河南省职业病医院河南省辐射生物与流行病学医学重点实验室,河南郑州 450052
- 折叠
摘要
目的 对放射工作人员的微核率进行分析,为长期接受低水平电离辐射的放射工作人员提供更加准确的职业健康监护依据.方法 放射组为在岗期间接触射线的353名放射工作人员,对照组为上岗前尚未接触射线的41名放射工作人员.采用胞质分裂阻断微核法测定微核率.结果 放射组平均微核率明显高于对照组平均微核率(t=-2.95,P＜0.05).放射组中,随着年龄的增加,微核率逐渐增加,差异具有统计学意义(F=8.36,P＜0.05).10～年和30～年工龄组人员微核率明显高于＜10年工龄组人员的微核率(x2=-44.79,-60.47,P＜0.05).女性微核率明显高于男性微核率(t=3.93,P＜0.05);放射诊断学组和探伤组的微核率明显高于对照组(t=3.51,3.65,P＜0.05).结论 微核率在长期接触低水平电离辐射的放射工作人员中有所增加,有必要进一步加强对放射工作人员特别是最大的辐射暴露工作者群体医务人员的职业健康监护和辐射防护教育.
Abstract
Objective To analyze the micronucleus rate of radiation workers and to provide accurate occupational health monitoring basis in radiation workers exposed to low-level ionizing radiation for a long time.Methods The radiation group consisted of 353 radiation workers who had been exposed to ionizing radiation during work,while the control group con-sisted of 41 radiation workers who had not yet been exposed to ionizing radiation before work.The cytokinesis-block micro-nucleus method was used to determine the micronucleus rate.Results The average micronucleus rate in the radiation group was significantly higher than that in the control group(t=-2.95,P＜0.05).In the radiation group,the micronucleus rate gradually increased with age,and the difference was statistically significant(F=8.36,P＜0.05).The micronucleus rates of workers with＞10 and＞30 years of service were significantly higher than those of workers with＜10 years of service(x2=-44.79,-60.47,P＜0.05).The micronucleus rate in females was significantly higher than that in males(t=3.93,P＜0.05).The micronucleus rates in the diagnostic radiology group and the industrial detection group were significantly higher than that in the control group(t=3.51,3.65,P＜0.05).Conclusion The micronucleus rate has increased among the radiation workers exposed to low-level ionizing radiation for a long time.It is necessary to further strengthen occupational health mon-itoring and radiation protection education for radiation workers,especially the medical workers that constitute the largest population of radiation exposure workers.
关键词
CB微核法/低水平电离辐射/放射工作人员/微核率Key words
Cytokinesis-block micronucleus method/Low-level ionizing radiation/Radiation worker/Micronucleus rate引用本文复制引用
出版年
2024
NETL
NSTL
万方数据