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口服尿素14C所致人体剂量转换系数

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目的 计算口服尿素14C情况下,人体各器官受照剂量及其剂量转换系数,为评估中国人摄入尿素14C所致内照射剂量提供简便方案.方法 在FLUKA软件中导入中国参考人体素模型,模拟不同器官受到14C内照射时,各个器官的吸收剂量,得到口服尿素14C时的剂量转换系数.结果 胃、结肠、膀胱、心脏、肌肉等组织器官的吸收剂量转换系数分别为:阴性情况,0.029、0.029、0.32(0.24)、0.028、0.029;阳性情况,0.079、0.078、0.18(0.15)、0.076、0.080,单位mGy/MBq.待积有效剂量转换系数为:阴性,0.041(0.037);阳性,0.082(0.081),单位mSv/MBq.结论 本文得到的剂量转换系数可为评估中国人口服尿素14C药物后的受照剂量提供重要参数.
Dose conversion coefficients for humans after oral administration of urea-14C
Objective To calculate the absorbed doses and conversion coefficients of various organs in humans after oral administration of urea-14C,and to provide a convenient method for evaluating the internal radiation dose caused by ingestion of urea-14C in Chinese population.Methods The Chinese reference human voxel model was imported into the FLUKA software to simulate the absorbed doses to organs under internal exposure to 14C,and to obtain the dose conversion coeffi-cients for oral administration of urea-14C.Results The absorbed dose conversion coefficients for the stomach,colon,blad-der,heart,and muscles were 0.029,0.029,0.32(0.24),0.028,and 0.029 mGy/MBq in negative cases,and 0.079,0.078,0.18(0.15),0.076,and 0.080 mGy/MBq in positive cases.The committed effective dose coefficients were 0.041(0.037)mSv/MBq in negative cases and 0.082(0.081)mSv/MBq in positive cases.Conclusion The dose conversion coefficients obtained in this study can provide important parameters for evaluating the absorbed dose to Chinese population after oral ad-ministration of urea-14C.

Absorbed doseUrea-14CVoxel modelConversion coefficient

张震、唐光毅、马忠剑、朱卫国、陈飞

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国家卫生健康委职业安全卫生研究中心,国家卫生健康委粉尘危害工程防护重点实验室,北京 102308

中国科学院高能物理研究所,北京 100049

中国疾病预防控制中心辐射防护与核安全医学所,北京 100088

吸收剂量 尿素14C 体素模型 转换系数

2024

中国辐射卫生
中华预防医学会 山东省医科院放射医学研究所

中国辐射卫生

CSTPCD
影响因子:0.35
ISSN:1004-714X
年,卷(期):2024.33(2)
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