Impact of radioactive impurity nuclides in 90Y microspheres on the therapeutic dose of pancreatic tumors
Objective To evaluate the effects of radioactive impurity nuclides in 90Y glass microsphere on therapeutic dose during radioembolization of pancreatic cancer.To provide a reference for correction of the dose calculated for individuals with different pancreatic tumors.Methods In this study,the radioactive impurity nuclide composition of 90Y glass micro-sphere samples was analyzed to determine the source term of Monte Carlo calculation.Then,according to the PET/CT med-ical imaging data of pancreatic cancer patients,the three-dimensional modeling software Solidworks 2020 was used to con-struct the real and personalized digital human digestive system model of pancreatic cancer patients at a resolution showing the vascular distribution in pancreas and tumor.Finally,the Monte Carlo program GATE 8.2 was used to simulate the three-dimensional radiation dose fields of radioactive impurity nuclides 91Y and 65Zn from 90Y glass microspheres in various tis-sues and organs.The three-dimensional dose fields were visualized to analyze the influence of radioactive impurity nuclides on therapeutic dose.Results The three-dimensional radiation dose fields of 91Y and 65Zn from 90Y glass microspheres demonstrated two dose extreme points.The maximum dose value of 91Y to tissue was 0.272 mGy and the maximum dose value of 65Zn to tissue was 9.34 μGy,with average statistical errors of less than 3.2%.Conclusion The impact of radioact-ive impurity nuclides 91Y and 65Zn in 90Y glass microsphere sample on therapeutic dose is minimal and can be neglected.
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